Biocompatible hydrophilic complexes and process for preparation and use
AssigneeUnion Carbide Chemicals & Plastics Technology Corporation
InventorsYou-Ling Fan, Lawrence Marlin
Life of this patent
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Abstract
Biocompatible polymeric complexes having utility in many fields including medical applications, as well as personal and health care, are provided and can be affixed to a variety of substrate materials which themselves may or may not also be biocompatible. The complexes of this invention are comprised of a carboxylic acid polymer with either a poly(lower-alkylene oxide) or a poly(N-vinyl lactam). Moreover, a complex of an antimicrobial agent such as iodine can be formed with the complex to provide antimicrobial activity. The complexes are also useful for forming biocompatible coatings on medical devices, some of which can render the surface lubricious when exposed to aqueous or body fluids.
Claims45
A method of covering at least a portion of a substrate with a hydrophilic polymeric complex to provide a biocompatible surface said method consisting essentially of:
- (1) contacting said substrate with a polyisocyanate contained in a first inert solvent to provide at least a partially coated substrate;
- (2) contacting said coated substrate with a carboxylic acid containing polymer contained in a second inert solvent to provide a multiple coated substrate and optionally one or more additives selected from the group consisting of stabilizers, antioxidants, antimicrobial agents, antithrombogenic agents, colorants and biological agents;
- (3) contacting said multiple coated substrate with a third inert solvent containing at least one member of the group consisting of a poly (N-vinyl lactam)
- and a poly (lower-alkylene oxide) and optionally one or more additives selected from the group consisting of stabilizers, antioxidants, antimicrobial agents, antithrombogenic agents, colorants and biological agents;
- and
- (4) thereafter drying said multiple coated substrate.
A method of covering at least a portion of a substrate with a hydrophilic polymeric complex to provide a biocompatible surface said method consisting essentially of:
- (1) contacting said substrate with a polyisocyanate contained in a first inert organic solvent to provide at least a partially coated substrate;
- (2) contacting said coated substrate with a poly(acrylic acid) polymer of the formula:
- ##STR2## where n=0-0.95 mole fraction of neutralized acid moieties;
- m=0.05-1.0 mole fraction of acid moieties with the proviso that n=m=1;
- X.sub.1, X.sub.2, X.sub.3 are each a hydrogen atom or a monovalent organic radical;
- Y is a single bond or a divalent organic radical;
- Z is a metallic ion or a tertiary ammonium ion;
- and
- p is a number such that the polymer has a molecular weight between about 200,000 and about 5,000,000;
- said poly(acrylic acid) contained in a second inert organic solvent to provide a multiple coated substrate;
- (3) contacting said multiple coated substrate with a third solvent containing at least one polymeric compound selected from the group consisting of a poly(vinyl pyrrolidone) and a poly(ethylene oxide);
- and
- (4) thereafter drying said multiple coated substrate.
A method of covering at least a portion of a substrate with a hydrophilic polymeric complex to provide a biocompatible surface said method consisting essentially of:
- (1) contacting said substrate with a blend of a polyisocyanate and a poly(acrylic acid) polymer of the formula:
- ##STR3## where n=0-0.95 mole fraction of neutralized acid moieties;
- m=0.05-1.0 mole fraction of acid moieties with the proviso that n+m=1;
- X.sub.1, X.sub.2, X.sub.3 are each a hydrogen atom or a monovalent organic radical:
- Y is a single bond or a divalent organic radical;
- Z is a metallic ion or a tertiary ammonium ion;
- and
- p is a number such that the polymer has a molecular weight between about 200,000 and about 5,000,000;
- said blend of polyisocyanate and poly(acrylic acid) contained in an inert organic solvent in which said polyisocyanate and poly(acrylic acid) are dispersible;
- (2) contacting said multiple coated substrate with a second solvent containing at least one polymeric compound selected from the group consisting of a poly(vinyl pyrrolidone) and a poly(ethylene oxide);
- and
- (3) thereafter drying said multiple coated substrate.
Dependencies are inferred from the claim text.