4-substituted 2-aminoalk-3-enoic acids
AssigneeCiba-Geigy Corporation
InventorsChristof Angst, Hans Allgeier, Roland Heckendorn, Daniel Wallach
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Abstract
Substituted 2-aminoalk-3-enoic acid derivative of formula I ##STR1## wherein R.sub.1 is an aliphatic hydrocarbon radical that is substituted by optionally acylated or aliphatically or araliphatically etherified hydroxy, by halogen, by optionally acylated and/or aliphatically substituted amino or by an aza-, diaza-, azoxa- or oxa-cycloaliphatic radical, or is an oxacycloaliphatic hydrocarbon radical bonded via a carbon atom, or is an optionally aliphatically N-substituted or N-acylated azacycloaliphatic hydrocarbon radical, and R.sub.2 is free or esterified carboxy, and their salts exhibit NMDA-antagonistic properties and are useful as active ingredients of anticonvulsive medicaments.
Claims11
A compound of formula I, ##STR10## wherein R.sub.1 is lower alkanoyloxy-lower alkyl or benzoyloxy-lower alkyl, lower alkoxy-lower alkyl or phenyl-lower alkoxy-lower alkyl, 6-aminohexyl, lower alkyl 6-aminohexyl or di-lower alkyl 6-aminohexyl and R.sub.2 is carboxy, lower alkoxycarbonyl, 4- up to and including 7-membered cycloalkoxycarbonyl or phenyl-lower alkoxycarbonyl, any phenyl radicals in R.sub.1 and/or R.sub.2 being unsubstituted or mono-, di- or tri-substituted by lower alkyl, lower alkoxy, halogen, cyano and/or by trifluoromethyl, or a salt thereof.
Dependencies are inferred from the claim text.