US 5,294,724 A · 4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters and a process for their preparation

Abstract

4-Hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, process for their preparation, their use as pharmaceuticals, and pharmaceutical preparations and precursors. Compounds of the formula I ##STR1## and the corresponding open-chain dihydroxycarboxylic acids of the formula II ##STR2## in which X, Y, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings indicated, and also their pharmacologically tolerable salts with bases and their pharmacologically tolerable esters, processes for the preparation of these compounds, their use as pharmaceuticals and pharmaceutical preparations are described. In addition, compounds of the formula III ##STR3## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X and Y have the meanings indicated are described.

Claims3

Dependent claims

A 4-hydroxytetrahydropyran-2-one of formula I ##STR34## or the corresponding open-chain dihydroxycarboxylic acid of formula II ##STR35## wherein X is oxygen;

Y is oxygen or sulfur;
R.sup.1 is isopropyl or cyclopropyl;
R.sup.2 is hydrogen, isopropyl or p-fluorophenyl;
R.sup.3 is hydrogen, acetyl, isopropyl, p-fluorophenyl, or one of the radicals ##STR36## wherein M is hydrogen or sodium;
R.sup.4 is hydrogen, isopropyl or p-fluorophenyl;
and
R.sup.5 is isopropyl or p-fluorophenyl;
and pharmaceutically acceptable salt or pharmaceutically acceptable ester thereof.

5 more elements

Dependencies are inferred from the claim text.

4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters and a process for their preparation

Life of this patent

4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters and a process for their preparation

Life of this patent

Abstract

Claims3