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US 5,294,715 AGranted
Acridine-intercalator based hypoxia selective cytotoxins
AssigneeUniversity of Pittsburgh
InventorsMaria Papadopoulou-Rosenzweig, William D. Bloomer, William D. Bloomer
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Abstract
Hypoxia selective cytotoxins of the general formula ##STR1## wherein n is from 1 to 5, and NO.sub.2 is in at least one of the 2, 4 or 5-positions of the imidazole. Such compounds have utility as radiosensitizers and chemosensitizers.
Claims4
A hypoxia selective cytotoxin of the formula ##STR6## wherein n is from 1 to 5, and NO.sub.2 is in the 2, 4 or 5-position of the imidazole.
Dependencies are inferred from the claim text.