Immunosuppressive agents
AssigneeMonsanto Company
InventorsPeter D. Arkwright, Raymond A. Dwek, Christopher W. G. Redman, Graham A. W. Rook, thomas W. Rademacher
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Abstract
The disclosure describes novel immunosuppressive agents isolated from syncytiotrophoblast microvilli membranes by preparing a minutely subdivided and solubilized preparation of said membranes and isolating the unreduced N-linked oligosaccharides from an extract of said preparation.
Claims1
An immunosuppressive agent obtained by the process comprising minutely subdividing and solubilizing syncytiotrophoblast microvilli membranes, releasing the unreduced N-linked oligosaccharides from the resulting solubilized preparation, digesting the released oligosaccharides with sialidase, fractionating the oligosaccharides into neutral and acidic fractions as shown in FIG. 5(a) and FIG. 5(b), respectively and recovering the neutral fraction.
Dependencies are inferred from the claim text.