Imidazolyl-propenoic acid derivatives
AssigneeBayer Aktiengesellschaft
InventorsThomas Kramer, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Stefan Wohlfeil
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Abstract
Imidazolyl-propenoic acid derivatives can be prepared by reaction of aldehydes with phosphonoacetic acid esters. The imidazolyl-propenoic acid derivatives are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.
Claims9
An imidazolyl-propenoic acid derivative of the formula ##STR11## in which R.sup.1 represents straight-chain or branched alkyl or alkenyl each having up to 8 carbon atoms, each of which is optionally substituted by cycloalkyl having 3 to 6 carbon atoms, or represents cycloalkyl having 3 to 8 carbon atoms,
- R.sup.2 represents hydrogen, halogen, hydroxyl, nitro, cyano, trifluoromethyl, trifluoromethoxy or pentafluoroethyl, or represents straight-chain or branched alkyl having up to 6 carbon atoms, or represents aryl having 6 to 10 carbon atoms,
- R.sup.3 represents hydrogen, straight-chain or branched alkyl having up to 8 carbon atoms or phenyl,
- R.sup.4 and R.sup.5 are identical or different and represent hydrogen, halogen, cyano, nitro, trifluoromethyl, hydroxyl, trifluoromethoxy or straight-chain or branched alkyl or alkoxy each having up to 6 carbon atoms,
- R.sup.6 represents hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms,
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.