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AssigneeMeiji Seika Kaisha, Ltd.
InventorsTomoya Machinami, Kazue Yasufuku, Seiji Shibahara, Fumiya Hirano, Yasukatsu Yuda, Motohiro Nishio, Yuji Matsuhashi, Takashi Tsuruoka, Kiyoaki Katano, Shigeharu Inoye
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A novel benzothiazole or benzimidazole derivative represented by formula (I) ##STR1## wherein X represents a sulfur atom or a NH group; R.sup.1 represents a hydrogen atom, a lower alkoxy group, a chlorine atom, a bromine atom or an iodine atom; R.sup.2 represents a hydrogen atom a substituted or unsubstituted lower alkyl group, a vinyl group, an aryl group or an acyl group; m is an integer of 1, 2 or 3; and n is an integer of 0, 1 or 2, which shows an excellent acid secretion suppressing effect and gastric mucosa protecting effect, and an antiulcer agent containing the same as an active ingredient.
An antiulcer agent containing, as an active ingredient, a compound selected from the group consisting of 5-chloro-2-[(2-ethoxyethyl)sulfinyl]benzothiozole, 2-[(2-ethoxyethyl)-sulfinyl]benzothiozole, 5-chloro-2-[(2-hydroxyethyl)sulfinyl]-benzothiozole, 5-chloro-2-[2-{2-(2-hydroxyethoxy)ethoxy}ethylsulfinyl]benzothiozole and 2-[2-ethoxyethyl)sulfinyl]benzimidazole.
A method of preventing and/or treating peptic ulcer which comprises administering to a patient an antiulcer agent containing, as an active ingredient, a compound selected from the group consisting of 5-chloro-2-[(2-ethoxyethyl)sulfinyl]benzothiozole, 2-[(2-ethoxyethyl)sulfinyl]benzothiozole, 5-chloro-2-[(2-hydroxyethyl)sulfinyl]benzothiozole, 5-chloro-2-[2-{2-(2-hydroxyethoxy)ethoxy}ethylsulfinyl]benzothiozole and 2-[2-ethoxyethyl)sulfinyl]benzimidazole.
5-Chloro-2-[(2-ethoxyethyl)sulfinyl]benzothiazole.
2-[(2-Ethoxyethyl)sulfinyl]benzothiazole.
5-Chloro-2-[(2-hydroxyethyl)sulfinyl]benzothiazole.
5-Chloro-2-{2-(2-hydroxyethoxy)ethoxy}ethylsulfinyl]benzothiazole.
2-[2-Ethoxyethyl)sulfinyl]benzimidazole.
Dependencies are inferred from the claim text.