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US 5,294,624 AGranted
Antihyperlipidemic cinnamide derivatives
AssigneeKanegafuchi Kagaku Kogyo Kabushiki Kaisha
InventorsYoshihide Fuse, Kenji Fujii, Keiji Kameyama, Taizo Kawabe, Toshiaki Miwa, Ikuo Katsumi
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Abstract
Novel cinnamamide derivatives and the salts thereof are provided. An antihyperlipidemic composition is also provided. The composition comprises an active ingredient which is at least one selected from the group consisting of the above-mentioned cinnamamide derivative and the pharmaceutically acceptable salt thereof.
Claims8
A cinnamamide derivative of formula I or the salts thereof:
- ##STR116## Wherein R.sup.1 is selected from the group consisting of
- --(CH.sub.2).sub.n 7OR.sup.12,
- wherein
- R.sup.12 is --COR.sup.14 (R.sup.14 is pyridyl), and n.sup.7 is an integer of 1 to 3;
- --(CH.sub.2).sub.n 8SR.sup.15
- wherein R.sup.15 is --(CH.sub.2).sub.n 11R.sup.18 (R.sup.18 is pyridyl, and n.sup.11 is an integer of 0 to 3), and n.sup.8 is an integer of 1 to 3;
- --(CH.sub.2).sub.n 12NHR.sup.19,
- wherein
- R.sup.19 is --COR.sup.21 (R.sup.21 is pyridyl), and n.sup.12 is an integer of 1 to 3;
- R.sup.2 is selected from the group consisting of hydrogen, alkyl having 1 to 5 carbon atoms, and --(CH.sub.2).sub.n 19-C.sub.6 H.sub.5 (n.sup.19 is an integer of 1 to 3);
- or
- R.sup.1 and R.sup.2 may be linked together with the amide nitrogen to form a ring of ##STR117## which is ##STR118## (R.sup.43 is hydrogen or alkyl having 1 to 3 carbon atoms).
9 more elements
Dependencies are inferred from the claim text.