Substituted quinolines and cinnolines

A compound of the formula ( 1) ##STR11## wherein:

• R.sup.1 to R.sup.4 are independently
• H, halo, (C.sub.1 -C.sub.4) alkyl, branched (C.sub.3 -C.sub.4) alkyl, halo (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkoxy, NO.sub.2, or NH.sub.2, at least two of R.sup.1 to R.sup.4 being H,
• W is CR.sup.5 ;
• R.sup.5 is H, CH.sub.3, or Cl,:
• R.sup.6 is H, CH.sub.3, Cl, or Br;
• A is --O--(CH.sub.2).sub.2 --Ar, --NR.sup.7 --(CH.sub.2).sub.2 --Ar, or --CR.sup.8 R.sup.9 --(CH.sub.2).sub.2 --Ar;
• R.sup.7 is H, (C.sub.1 -C.sub.4) alkyl, or acetyl;
• R.sup.8 and R.sup.9 are independently H, (C.sub.1 -C.sub.4) alkyl, halo, or OH, or R.sup.8 and R.sup.9 combine to form a saturated or unsaturated carbocyclic ring comprising three to seven carbon atoms;
• and
• Ar is
• 1. 3-benzodioxolyl
• fluorenyl,
• pyridyl,
• substituted pyridyl,
• indolyl,
• furanyl,
• substituted furanyl,
• thienyl, optionally substituted with CH.sub.3 or Cl,
• thiazolyl,
• cyclopentyl,
• 1-methylcyclopentyl,
• cyclohexenyl (tetrahydrophenyl),
• cyclohexyl (hexahydrophenyl),
• naphthyl,
• substituted naphthyl,
• dihydronaphthyl,
• tetrahydronaphthyl,
• decahydronaphthyl, or
• a group of formula (2):
• ##STR12## where R.sup.10 to R.sup.14 are independently H, halo, (C.sub.1 -C.sub.10) alkyl, branched (C.sub.3 -C.sub.6) alkyl, halo (C.sub.1 -C.sub.7) alkyl, (C.sub.1 -C.sub.7) alkoxy, halo (C.sub.1 -C.sub.7) alkoxy, phenoxy, substituted phenoxy, phenylthio, substituted phenylthio, phenyl, substituted phenyl, NO.sub.2, NH.sub.2, acetoxy, OH, CN, SiR.sup.15 R.sup.16 R.sup.17, or OSiR.sup.15 R.sup.16 R.sup.17, where R.sup.15, R.sup.16, and R.sup.17 are independently (C.sub.1 -C.sub.4) alkyl or (C.sub.3 -C.sub.4) branched alkyl, phenyl, or substituted phenyl, provided that unless each of R.sup.10 to R.sup.14 is F or CH.sub.3, then at least two of R.sup.10 to R.sup.14 are H;
• or an acid addition salt of a compound of formula (1) or an N-oxide of a compound of formula (1) when W is CR.sup.5
• where, in the foregoing definitions, the term substituted phenyl refers to phenyl substituted with up to three groups selected from halo (C.sub.1 -C.sub.10) alkyl, branched (C.sub.3 -C.sub.6) alkyl, halo (C.sub.1 -C.sub.7) alkyl, hydroxy (C.sub.1 -C.sub.7) alkyl, (C.sub.1 -C.sub.7) alkoxy, halo (C.sub.1 -C.sub.7) alkoxy, phenoxy, phenyl, NO.sub.2, OH, CN, (C.sub.1 -C.sub.4) alkanoyloxy, or benzyloxy;
• the term substituted phenoxy refers to a phenoxy group substituted with up to three groups selected from halo, (C.sub.1 -C.sub.10) alkyl, branched (C.sub.3 -C.sub.6) alkyl, halo (C.sub.1 -C.sub.7) alkyl, hydroxy (C.sub.1 -C.sub.7) alkyl, (C.sub.1 -C.sub.7) alkoxy, halo (C.sub.1 -C.sub.7) alkoxy, phenoxy, phenyl, NO.sub.2, OH, CN (C.sub.1 -C.sub.4) alkanoyloxy, or benzyloxy;
• the term substituted phenylthio refers to a phenylthio group substituted with up to three groups selected from halo, (C.sub.1 -C.sub.10) alkyl, branched (C.sub.3 -C.sub.6) alkyl, halo (C.sub.1 -C.sub.7) alkyl, hydroxy (C.sub.1 -C.sub.7) alkyl, (C.sub.1 -C.sub.7) alkoxy, halo (C.sub.1 -C.sub.7) alkoxy, phenoxy, phenyl, NO.sub.2, OH, CN (C.sub.1 -C.sub.4) alkanoyloxy, or benzyloxy;
• the term substituted phenylsulfonyl refers to a phenylsulfonyl group substituted with up to three groups selected from halo (C.sub.1 -C.sub.10) alkyl, branched (C.sub.3 -C.sub.6) alkyl, halo (C.sub.1 -C.sub.7) alkyl, hydroxy (C.sub.1 -C.sub.7) alkyl, (C.sub.1 -C.sub.7) alkoxy, halo (C.sub.1 -C.sub.7) alkoxy, phenoxy, phenyl, NO.sub.2, OH, CN (C.sub.1 -C.sub.4) alkanoyloxy, or benzyloxy;
• and
• the terms substituted naphthyl, substituted pyridyl, and substituted furanyl refer to these ring systems substituted with halo, halo (C.sub.1 -C.sub.4), CN, NO.sub.2, (C.sub.1 -C.sub.4) alkyl, (C.sub.3 -C.sub.4) branched alkyl, phenyl, (C.sub.1 -C.sub.4) alkoxy, or halo (C.sub.1 -C.sub.4) alkoxy;
• provided that if A is NR.sup.7 --(CH.sub.2).sub.2 --Ar then Ar is a group of formula (2) wherein four of R.sup.10 to R.sup.14 are H and one of R.sup.10 to R.sup.14 is Cl, (C.sub.1 -C.sub.4) alkyl, halo (C.sub.1 -C.sub.4) alkyl, branched (C.sub.3 -C.sub.6) alkyl, (C.sub.1 -C.sub.4) alkoxy, halo (C.sub.1 -C.sub.4) alkoxy, phenyl, substituted phenyl, phenoxy, or substituted phenoxy.