Guanidinoalkyl-1,1-bisphosphonic acid derivatives, process for their preparation and their use

A compound of the formula 1a, 1b or 1c ##STR21## or a physiologically tolerable salt of the compound of the formula Ia, Ib or Ic, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are identical or different and independently of one another have the meaning below

• a) a hydrogen atom,
• b) (C.sub.1 -C.sub.7)-alkyl, straight-chain or branched,
• c) (C.sub.1 -C.sub.7)-alkyl, straight-chain or branched, mono- or polysubstituted by
• 1) a halogen atom,
• d) (C.sub.3 -C.sub.10)-cycloalkyl,
• e) (C.sub.3 -C.sub.10)-cycloalkyl, mono- or polysubstituted by
• 1) (C.sub.1 -C.sub.4)-alkyl, straight-chain or branched,
• f) a radical of the formula II ##STR22## in which R.sup.12, R.sup.13 and R.sup.14 are identical or different and independently of one another have the meaning below
• 1) a hydrogen atom,
• 2) a halogen atom,
• 3) (C.sub.1 -C.sub.5)-alkyl, straight-chain or branched,
• 4) (C.sub.1 -C.sub.5)-alkyl, straight-chain or branched, mono- or polysubstituted by
• 4.1 a halogen atom,
• 5) --(SO.sub.2)--CH.sub.3 or
• 6) --O--CH.sub.3,
• and p is zero, 1, 2, 3 or 4
• g) R.sup.2 and R.sup.3, R.sup.2 and R.sup.5 or R.sup.4 and R.sup.5, together with the two nitrogen atoms to which they are bonded, form
• 1) a monocyclic 5-, 6- or 7-membered heterocyclic ring, where the said ring is saturated or unsaturated and mono- or polysubstituted by
• 1.1 a hydrogen atom,
• 1.2 a halogen atom,
• 1.3 --O--(C.sub.1 -C.sub.5)-alkyl,
• 1.4 oxo or
• 1.5 ##STR23## or 2) a bicyclic 9- or 10-membered heterocyclic ring system, where this ring system is unsaturated and mono- or polysubstituted as defined in g) 1.1 to g) 1.5 or 2 carbon atoms in this ring system are replaced by nitrogen atoms, or
• h) R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4, together with the nitrogen atoms to which they are bonded, form a mono- or bicyclic 3- to 10-membered ring, where the ring is saturated or unsaturated and mono- or polysubstituted as defined in g) 1.1 to g) 1.5,
• i) R.sup.1, R.sup.2, R.sup.3 or R.sup.4 is a mono- or bicyclic 3- to 10-membered ring, where the ring is saturated or unsaturated and mono- or polysubstituted as defined in g) 1.1 to g) 1.5, or
• j) R.sup.2 is ##STR24## where R.sup.18 is a) a hydrogen atom,
• b) (C.sub.1 -C.sub.5)-alkyl, straight-chain or branched, or
• c) phenyl,
• l is an integer from 0 to 7,
• m is zero, 1 or 2,
• n is an integer from 0 to 7,
• the sum of the numbers l, m and n is equal to 10 or less than 10,
• R.sup.8, R.sup.9, R.sup.10 and R.sup.11 are identical or different and independently of one another have the meaning below
• a) a hydrogen atom,
• b) (C.sub.1 -C.sub.5)-alkyl, straight-chain or branched, or
• c) phenyl,
• X is
• a) a hydrogen atom,
• b) hydroxyl,
• c) a halogen atom, or
• d) (C.sub.1 -C.sub.4)-alkyl, in the case in which l, m and n are zero,
• excluding the compound tetraethyl 1-((aminoiminomethyl)amino)methane-1,1-bisphosphonate.