Inhibitor of platelet aggregation
AssigneeThe General Hospital Corporation
InventorsEthan A. Lerner, Michael R. Lerner
Life of this patent
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Abstract
Purified DNA comprising a sequence encoding chrysoptin. Chrysoptin can be used to alter the hemodynamic or hemostatic properties of an animal's blood by administering to the animal an effective amount of chrysoptin.
Claims28
Purified DNA comprising a sequence that hybridizes under high stringency to a naturally occurring Chrysops nucleic acid encoding the amino acid sequence of Val-Ser-Tyr-Cys-Ser-Leu-Pro-Cys-Arg-Gly-Asp-Ser-His-Val-Gly-Cys-Gly-Glu-Al a-Ala-Tyr-Gly-Val-Glu-Cys-Gly-Gln-Ser-Pro-Arg (Seq. ID No. 1), the amino acid sequence Phe-Trp-Leu-Pro-Gly-Gln-Leu-Asn-Phe-Glu-Tyr-Thr-Gly-Asp-Lys-Leu-Pro-Arg (Seq. ID No. 2), the amino acid sequence Ala-Leu-Leu-Thr-Cys-Asn-Phe-Ser-Ser-Asp-Asn-Ile-Tyr-Gly-Arg-Pro-Val-Tyr-Ly s (Seq. ID No. 3), or the amino acid sequence Thr-Cys-Asn-Phe-Ser-Ser-Asp-Asn-Asp-Tyr-Asn-Arg-Pro-Val-Try-Lys-Thr-Gly-Se r-Ser-Pro-Ala-Glu-Lys-Cys-Ile-Lys-Lys- Asp-Lys-Thr-Phe-Lys-Asn-Leu-Cys-Ser-Ala-Glu-Glu-Pro-Ile-Asp-Pro-Asn-Gln-Hi s-Asn-Phe (Seq. ID No. 6).
Purified DNA comprising a sequence which encodes a peptide which is at least 90 percent homologous with the amino acid sequence of Val-Ser-Tyr-Cys-Ser-Leu-Pro-Cys-Arg-Gly-Asp-Ser-His-Val-Gly-Cys-Gly-Glu-Al a-Ala-Tyr-Gly-Val-Glu-Cys-Gly-Gln-Ser-Pro-Arg (Seq. ID No. 1), the amino acid sequence Phe-Trp-Leu-Pro-Gly-Gln-Leu-Asn-Phe-Glu-Tyr-Thr-Gly-Asp-Lys-Leu-Pro-Arg (Seq. ID No. 2), the amino acid sequence Ala-Leu-Leu-Thr-Cys-Asn-Phe-Ser-Ser-Asp-Asn-Ile-Tyr-Gly-Arg-Pro-Val-Tyr-Ly s (Seq. ID No. 3), or the amino acid sequence Thr-Cys-Asn-Phe-Ser-Ser-Asp-Asn-Asp-Tyr-Asn-Arg-Pro-Val-Try-Lys-Thr-Gly-Se r-Ser-Pro-Ala-Glu-Lys-Cys-Ile-Lys-Lys-Asp-Lys-Thr-Phe-Lys-Asn-Leu-Cys -Ser-Ala-Glu-Glu-Pro-Ile-Asp-Pro-Asn-Gln-His-Asn-Phe (Seq. ID No. 6), said peptide having the ability of inhibit platelet aggregation at least 10% as effectively as does native chrysoptin.
Purified DNA comprising a sequence which encodes the amino acid sequence of Val-Ser-Tyr-Cys-Ser-Leu-Pro-Cys-Arg-Gly-Asp-Ser-His-Val-Gly-Cys-Gly-Glu-Al a-Ala-Tyr-Gly-Val-Glu-Cys-Gly-Gln-Ser-Pro-Arg (Seq. ID No. 1), the amino acid sequence Phe-Trp-Leu-Pro-Gly-Gln-Leu-Asn-Phe-Glu-Tyr-Thr-Gly-Asp-Lys-Leu-Pro-Arg (Seq ID No. 2), the amino acid sequence Ala-Leu-Leu-Thr-Cys-Asn-Phe-Ser-Ser-Asp-Asn-Ile-Tyr-Gly-Arg-Pro-Val-Tyr-Ly s (Seq. ID No. 3), or the amino acid sequence Thr-Cys-Asn-Phe-Ser-Ser-Asp-Asn-Asp-Tyr-Asn-Arg-Pro-Val-Try-Lys-Thr-Gly-Se r-Ser-Pro-Ala-Glu-Lys-Cys-Ile-Lys-Lys-Asp-Lys-Thr-Phe-Lys-Asn-Leu-Cys -Ser-Ala-Glu-Glu-Pro-Ile-Asp-Pro-Asn-Gln-His-Asn-Phe (Seq. ID No. 6).
Dependencies are inferred from the claim text.