Residual protease-III
AssigneeOmnigene, Inc.
InventorsAlan Sloma, Gerald A. Rufo, Jr., Janice Pero
Life of this patent
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Abstract
A Bacillus cell containing a mutation in the residual protease III (rp-III) gene resulting in the inhibition of the production by the cell of proteolytically active RP-III.
Claims19
An isolated and purified Bacillus cell containing a mutation in the rp-III gene resulting in inhibition of the production by said cell of proteolytically active RP-III.
A method for producing a heterologous polypeptide in a Bacillus cell, said method comprising introducing into said cell a gene encoding said heterologous polypeptide, modified to be expressed in said cell, said Bacillus cell containing mutations in the rp-III, apr and npr genes.
Purified DNA consisting essentially of a Bacillus rp-III gene.
A vector comprising a Bacillus rp-III gene and regulatory DNA operationally associated with said gene.
Dependencies are inferred from the claim text.