Crosslinked, activatable, hydrophilic carrier beads
AssigneeRohm Co., Ltd.
InventorsErnst Goeldner, Dieter Kraemer, Ursula Artmann, Dieter Zwara
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Abstract
A copolymer, adaptable to use as a bead-like carrier material for affinity chromatography, of a hydrophilic allyl monomer of the formula CH.sub.2 .dbd.CH--CH.sub.2 --O--R--X.sub.n, wherein n is 0 and R is hydrogen, or n is a whole number from 1 to 5 and R is an (n+1)-valent aliphatic hydrocarbon group, and X is the same or different hydrophilic hydroxylic group, which copolymer is crosslinked by units of a polyfunctional comonomer in which at least two ethylenically unsaturated groups are linked by a chain containing a carbonamide or ether group.
Claims4
A highly crosslinked, alkali-resistant, hydrophilic activatable carrier consisting of beads of a copolymer consisting of (A) 10-90 percent by weight of an allylic monomer of the formula
- CH.sub.2 .dbd.CH--CH.sub.2 --O--R--X.sub.n,
- wherein n is 0 and R is hydrogen or n is a whole number from 1 to 5 and R is an (n+1)-valent aliphatic hydrocarbon having 1 to (n+4) carbon atoms, and X is the same or different and is selected from the group consisting of hydroxy and --(O--R').sub.m --OH, wherein R' is ethylene or propylene and m is a whole number from 1 to 45, and (B) 90 to 10 percent by weight of a crosslinking polyfunctional monomer having at least two ethylenically unsaturated, radically polymerizable groups linked by a chain containing a carbonamide or ether group, said beads having an average particle size of 3 microns to 1000 microns and being prepared by bead polymerization in inverted phase by dispersing an aqueous or aqueous-alcohol solution of the monomer as droplets in an organic liquid which is not totally miscible with water and initiating polymerization by addition of an initiator forming free radicals.
Dependencies are inferred from the claim text.