Back to results
US 5,294,441 AGranted
Avirulent microbes and uses therefor: salmonella typhi
AssigneeWashington University
InventorRoy Curtiss, III
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeWashington University
InventorRoy Curtiss, III
Estimating the term…
This invention provides immunogenic compositions for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of S. typhi. The derivatives having a mutation of the cya and/or crp and/or cdt genes. The invention also provides immunogenic compositions for the immunization of a vertebrate and invertebrate comprising an avirulent derivative of the above type which is capable of expressing a recombinant gene derived from a pathogen of said vertebrate or invertebrate individual to produce an antigen capable of inducing an immune response against said pathogen. Other embodiments of the invention include methods of preparing immunogenic compositions from these strains, and strains useful in the preparation of the immunogenic compositions, as well as methods of stimulating the immune system to respond to an immunogenic antigen of S. typhi by administration of the immunogenic composition.
An immunogenic composition for the immunization of an individual comprising a live avirulent S. typhi obtained from a pathogenic S. typhi strain, said avirulent S. typhi made avirulent by of an inactivating mutation in the structural cya gene and an inactivating mutation in the structural crp gene.
A method for stimulating the immune system of an individual to respond to an immunogenic antigen of S. typhi comprising administering to said individual the immunogenic composition comprising a live avirulent S. typhi obtained from a pathogenic S. typhi strain, said avirulent S. typhi made avirulent by an inactivating mutation in the structural cya gene and an inactivating mutation in the structural crp gene.
A method for stimulating the immune system of an individual to respond to an immunogenic antigen of a pathogen comprising administering to said individual an immunogenic composition comprising a live avirulent S. typhi obtained from a pathogenic S. typhi strain, said avirulent S. typhi made avirulent by an inactivating mutation in the structural cya gene and an inactivating mutation in the structural crp gene wherein said avirulent S. typhi expresses a recombinant gene from an agent pathogenic to said individual, to produce an antigen which induces an immune response in said individual against said pathogen.
An isolated avirulent strain of S. typhi obtained from a pathogenic strain of S. typhi said avirulent S. typhi made avirulent by an inactivating mutation in the structural cya gene and an inactivating mutation in the structural crp gene.
A method of preparing an immunogenic composition by suspending in a physiological excipient, an avirulent S. typhi obtained from a pathogenic strain of S. typhi, the avirulent S. typhi having an inactivating mutation in the structural cya gene and an inactivating mutation in the structural crp gene.
Dependencies are inferred from the claim text.