Process for producing 2-fluoro-4-(trifluoromethyl) acetanilide
AssigneeSumitomo Chemical Company, Limited
InventorsNoriyasu Sakamoto, Toshiaki Taki, Noritada Matsuo
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Abstract
Disclosed is a process for producing 2-fluoro-4-(trifluoromethyl) acetanilide which comprises reacting 3,4-difluorobenzotrifluoride with acetamide in the presence of a base in an aprotic polar solvent or in a mixture of an aprotic polar solvent and an aprotic non-polar solvent.
Claims12
A process for producing 2-fluoro-4-(trifluoromethyl) acetanilide which comprises reacting 3,4-di-fluorobenzotrifluoride with acetamide in the presence of alkali metal hydride or alkali metal carbonate in a solvent selected from the group consisting of at least one aprotic polar solvent and a mixture of at least one aprotic solvent and at least one aprotic non-polar solvent.
A process for producing 2-fluoro-4-(trifluoromethyl) acetanilide which comprises reacting 3,4-di-fluorobenzotrifluoride with acetamide in the presence of a non-nucleophilic base selected from the group consisting of alkali metal hydride and alkali metal carbonate in (i) at least one aprotic polar solvent selected from the group consisting of dimethylformamide, dimethyl sulfoxide, hexamethylphosphoric triamide, sulfolane, N-methylpyrrolidone, 1,3-dimethyl-2-imidazolidinone, 1,3-dimethyl-3,4,5,6-tetrahydro-2-(1H)-primidone, acetonitrile, tetrahydrofuran and dioxane, or (ii) a mixture of at least one of said aprotic polar solvents and aprotic non-polar solvent selected from the group consisting of C.sub.6 -C.sub.8 aromatic hydrocarbons, C.sub.6 -C.sub.8 aliphatic hydrocarbons, C.sub.1 -C.sub.6 halogenated hydrocarbons, and mixtures thereof.
Dependencies are inferred from the claim text.