Process for preparing .alpha.-chloro-.alpha.-oximino-4-hydroxyacetophenone
AssigneeHoechst Celanese Corporation
InventorsJohn R. Durrwachter, Charlet R. Lindley, Graham N. Mott
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Abstract
A process for the preparation of .alpha.-chloro-.alpha.-oximino-4-hydroxyacetophenone by reacting nitrosyl chloride with a mixture of 4-hydroxyacetophenone and a strong acid catalyst such as hydrogen chloride is disclosed. The nitrosyl chloride is introduced as a gas into the reactor to contact 4-hydroxyacetophenone and said acid catalyst dissolved in a solvent therein.
Claims18
A method for preparing .alpha.-chloro-.alpha.-oximino-4-hydroxyacetophenone, comprising the step of reacting 4-hydroxyacetophenone with nitrosyl chloride, said reaction being carried out in the presence of a strong acid catalyst which was added to the 4-hydroxyacetophenone before contacting with the nitrosyl chloride.
A method of producing .alpha.-chloro-.alpha.-oximino-4-hydroxyacetophenone, comprising the steps of:
- introducing nitrosyl chloride into a reactor from a source separate from the reactor;
- and contacting the nitrosyl chloride with a mixture of 4-hydroxyacetophenone and hydrogen chloride.
A method of producing .alpha.-chloro-.alpha.-oximino-4-hydroxyacetophenone having anti-bacterial and germicidal properties, comprising:
- a) reacting 4-hydroxyacetophenone with nitrosyl chloride in the presence of (i) a solvent which is selected from the group consisting of ethers, halogenated hydrocarbons and nitriles and (ii) hydrogen chloride which is added to the 4-hydroxyacetophenone prior to reacting with the nitrosyl chloride, and
- b) separating the produced .alpha.-chloro-.alpha.-oximino-4-hydroxyacetophenone from the reaction mass;
- said reaction being conducted (i) at a temperature of from about 0.degree. C. to about 20.degree. C.;
- (ii) at a pressure in the range of sub-atmospheric to slightly above atmospheric;
- and (iii) in the absence of an alkyl nitrite.
Dependencies are inferred from the claim text.