Process for the resolution of threo-3-[(2-aminophenyl)-thio]-2-hydroxy-3-(4-methoxy-phenyl)propionic acid
AssigneeRichter Gedeon Vegyeszeti Gyar Rt.
InventorsKalman Harsanyi, Elemer Fogassy, Maria cs, Tibor Gizur, Zsuzsanna Aracs nee Tischler, Katalin Berki, Laszlo Toke, Zsuzsanna Martonffy nee Jaszay
Life of this patent
Estimating the term…
Abstract
The invention relates to a novel process for the resolution of an acid mixture (hereinafter: threo acid mixture) containing (+)-threo-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)-propionic acid [hereinafter: (+)-threo acid]and (-)-threo-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)-propionic acid [hereinafter: (-)-threo acid].
Claims3
Process for the resolution of a threo-acid mixture containing (+)-threo-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)-propionic acid and (-)-threo-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid, which comprises
- a)
- (i) preparing a solution containing D-(-)-phenylglycine amide from a mixture containing same and L-(+)-phenylglycine amide by the use of (-)-threo-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)-propionic acid as resolving agent and using the solution obtained as a resolving agent for the resolution of the threo acid mixture;
- or
- (ii) using an acid addition salt of D-(-)-phenylglycine amide in a solid or dissolved form as a resolving agent,
- to obtain (-)-threo-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)-propionic acid;
- or
- b)
- (i) preparing a solution containing L-(+)-phenyl-glycine amide from a mixture containing L-(+)-phenylglycine amide and D-(-)-phenylglycine amide by the means of (+)-threo-3-[(2-aminophenyl)thio]-2-hydroxy-3-(4-methoxyphenyl)-propionic acid as resolving agent and using the solution obtained as a resolving agent for the resolution of the threo acid mixture;
- or
- (ii) using an acid addition salt of L-(+)-phenylglycine amide in a solid or dissolved form as a resolving agent to obtain (+)-threo-3-[(2-aminophenyl)thio]-2-hydroxy-3-4(4-methoxyphenyl)-propionic acid.
Dependencies are inferred from the claim text.