Substituted imidazole derivatives and their preparation and use
AssigneeFarmos-Yhtyma Oy
InventorsArto J. Karjalainen, Raimo E. Virtanen, Arja L. Karjalainen
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Abstract
Compounds of the formula: ##STR1## wherein X is --CH.sub.2 -- or ##STR2## R.sub.1 is H, C.sub.1-5 -alkyl or benzyl, which can be substituted or unsubstituted R.sub.2 is H, C.sub.1-4 -alkyl, OH or C.sub.1-3 -alkoxy R.sub.3 is H, CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3 or Hal R.sub.4 is H, CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3 or Hal and Hal is halogen and non-toxic acid addition salts and mixtures thereof are highly selective antagonists at postsynaptic .alpha..sub.2 -adrenoceptors, and are especially useful in the treatment of diabetes.
Claims30
A compound which is a substituted imidazole of the formula:
- ##STR11## or non-toxic, pharmaceutically acceptable salt thereof wherein X is --CH.sub.2 -- or ##STR12## R.sub.1 is H, C.sub.1-5 -alkyl or benzyl, which can be or unsubstituted or substituted by C.sub.1-3 alkyl, C.sub.1-3 alkoxy or halogen
- R.sub.2 is H, C.sub.1-4 -alkyl, OH or C.sub.1-3 -alkoxy
- R.sub.3 is H, CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3 or Hal
- R.sub.4 is H, CH.sub.3, CH.sub.2 CH.sub.3, OCH.sub.3 or Hal
- provided that when R.sub.2 is H, OH or C.sub.1-4 -alkyl then R.sub.1 cannot be hydrogen and when R.sub.2 is OH or C.sub.1-3 -alkoxy then X cannot be CO.
Dependencies are inferred from the claim text.