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US 5,292,879 AGranted
Intermediates for preparing cationic-2-heteroaryl-phenyl-carbapenem antibacterial agents
AssigneeMerck & Co., Inc.
InventorsFrank DiNinno, Ravindra N. Guthikonda, Susan M. Schmitt
Life of this patent
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Abstract
Carbapenem compounds of the formula ##STR1## are useful intermediates for preparing antibacterial agents.
Claims6
A compound of the formula:
- ##STR163## wherein;
- R is H or CH.sub.3 ;
- P' is a removable protecting group for hydroxy;
- M is a removable protecting group for carboxy;
- R.sup.a is selected from the group consisting of H, OP', Cl, Br, I, SCH.sub.3, CN, CHO, SOCH.sub.3, SO.sub.2 CH.sub.3, CO.sub.2 M, CH.sub.2 OP' or CONH.sub.2 ;
- and with the proviso that the --CH.sub.2 Z substituent is in the 2- or 3-position of the heteroaromatic ring;
- X is O or S, and
- Z is a leaving group selected from the group consisting of alkylsulfonyloxy, substituted alkylsulfonyloxy, arylsulfonyloxy, substituted arylsulfonyloxy, fluorosulfonyloxy, and halogen.
5 more elements
Dependencies are inferred from the claim text.