Substitution fluid preparation comprising 3-hydroxy-butyric acid (.beta.-hydroxybutric acid) and its salts
AssigneeKanegafuchi Kagaku Kogyo Kabushiki Kaisha
InventorsAtsushi Hiraide, Masami Katayama
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Abstract
The present invention provides a substitution fluid preparation which is characterized by containing at least one selected from 3-hydroxybutyric acid, 3-sodium hydroxybutyrate and 3-potassium hydroxybutyrate. The substitution fluid preparation of the present invention can be easily metabolized in the body of a patient to provide a good energy source and is also effective for suppressing increased protein catabolism in the living body.
Claims4
A method of supplying an energy source to a patient in a state of being substantially unable to metabolize carbohydrates, the method consisting of administering a substitution fluid preparation until said patient recovers the ability to metabolize carbohydrates, the preparation consisting essentially of:
- an effective amount of at least one compound selected from the group consisting of (R)-3-hydroxybutyric acid, (RS)-3-hydroxybutyric acid, sodium (R)-3-hydroxybutyrate, sodium (RS)-3-hydroxybutyrate, potassium (R)-3-hydroxybutyrate and potassium (RS) 3-hydroxybutyrate, and
- a pharmaceutically acceptable carrier.
A method for supplying an energy source to a patient in a state of being substantially unable to metabolize carbohydrates, which consists of administering a substitution fluid preparation consisting of
- (a) an effective amount of at least one compound selected from the group consisting of (R)-3-hydroxybutyric acid, (RS)-3-hydroxybutyric acid, sodium (R)-3-hydroxybutyrate, sodium (RS)-3-hydroxybutyrate, potassium (R)-3-hydroxybutyrate and potassium (RS)-3-hydroxybutyrate, and
- b) a pharmaceutically acceptable carrier, until said patient recovers the ability of metabolizing carbohydrates,
- and, after recovering said ability, administering a substitution fluid preparation consisting of
- (a) an effective amount of at least one compound selected from the group consisting of (R)-3-hydroxybutyric acid, (RS)-3-hydroxybutyric acid, sodium (R)-3-hydroxybutyrate, sodium (RS)-3-hydroxybutyrate, potassium (R)-3-hydroxybutyrate and potassium (RS)-3-hydroxybutyrate, and
- (b) an effective amount of at least one compound selected from the group consisting of amino acids, carbohydrates and inorganic salts,
- (c) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.