Substituted .beta.-diketones and their use
AssigneeOrion-yhtyma Oy
InventorsReijo J. Backstrom, Erkki J. Honkanen, Jarmo J. Pystynen, Anne M. Luiro, Paivi A. Aho, Inge-Britt Y. Linden, Erkki A. O. Nissinen, Pentti Pohto
Life of this patent
Estimating the term…
Abstract
Compound of formula ##STR1## wherein n is 0 or 1, R.sub.1 and R.sub.2 are independently methyl, ethyl or cyclopropyl and R is an optionally substituted phenyl or heteroaryl group or salt or ester thereof are useful in the treatment of inflammatory bowel disease.
Claims12
A method of treatment of inflammatory bowel disease by administering to a patient in need of such treatment a therapeutically effective amount of the compound of formula I ##STR10## wherein n is 0 or 1, R.sub.1 and R.sub.2 are independently methyl, ethyl or cyclopropyl and R is an unsubstituted or substituted phenyl;
- ##STR11## wherein X.sub.1 is hydrogen, hydroxy or C.sub.1-2 alkoxy which is unsubstituted or substituted by carbocyclic aryl;
- X.sub.2 and X.sub.3 are independently hydrogen, nitro, cyano, halo, trifluoromethyl, formyl, carboxy, acetamido, or the group
- R.sub.3 S(O).sub.m --
- wherein m is 0, 1 or 2 and R.sub.3 is C.sub.1-2 alkyl, carbocyclic aryl or carbocyclic aryl C.sub.1-2 alkyl;
- or carbamoyl which is unsubstituted or substituted by C.sub.1-2 alkyl, carbocyclic aryl C.sub.1-2 alkyl, aryl, or R is one of the following heteroaryl groups;
- ##STR12## wherein Y is oxygen or sulfur and X.sub.4 is hydrogen, nitro or halo;
- or a pharmaceutically acceptable salt or ester thereof to treat inflammatory bowel disease.
Dependencies are inferred from the claim text.