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US 5,292,769 AGranted
Substituted mandelic acid derivatives and their use in medicaments
AssigneeBayer Aktiengesellschaft
InventorsKlaus-Helmut Mohrs, Siegfried Raddatz, Michael Matzke, Romanis Fruchtmann, Armin Hatzelmann, Christian Kohlsdorfer, Reiner Muller-Peddinghaus, Pia Theisen-Popp
Life of this patent
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Abstract
Substituted mandelic acid derivatives can be prepared by reaction of glyoxylic esters with Grignard compounds. The substituted mandelic acid derivatives are suitable as active compounds in medicaments, in particular for medicaments which inhibit leukotriene synthesis.
Claims10
A substituted mandelic acid derivative compound of the formula:
- ##STR36## wherein M represents hydrogen, fluorine, chlorine, bromine, trifluoromethoxy or carboxyl;
- or
- represents straight-chain or branched alkyl which has up to 8 carbon atoms and is optionally substituted by hydroxyl, fluorine, chlorine or bromine;
- or
- represents straight-chain or branched alkoxy or alkoxycarbonyl having in each case up to 8 carbon atoms;
- or
- represents phenyl which is optionally substituted by fluorine, chlorine, bromine, nitro, cyano or by straight-chain or branched alkyl or alkoxy having in each case up to 6 carbon atoms;
- R.sub.1 represents a group of the formula:
- ##STR37## wherein n and m are identical or different and denote the number 1, 2, 3, 4, 5, 6 or 7;
- and
- R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 are identical or different and denote hydrogen, fluorine, chlorine, bromine, trifluoromethyl, trifluoromethoxy or straight-chain or branched alkyl or alkoxy having in each case up to 6 carbon atoms;
- R.sub.2 represents hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms;
- and
- R.sub.3 represents hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms;
- or a physiologically acceptable salt thereof.
12 more elements
Dependencies are inferred from the claim text.