Back to results
US 5,292,765 AGranted
Neuroprotection by indolactam V and derivatives thereof
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsDennis W. Choi, Dean M. Hartley
Life of this patent
Estimating the term…
Abstract
A method for reducing adverse effects of neurotoxic injury, which comprises administering to a patient susceptible to neurotoxic injury an effective amount, sufficient to reduce the injury, of a compound having an indolactam V ring system. Particularly preferred are compounds having ring stereochemistry as indicated in the following formula: ##STR1## The indicated substituents show preferred locations of substituents; preferred substituents are defined in the specification.
Claims12
A method for reducing adverse effects of neurotoxic injury, which comprises:
- administering to a patient susceptible to neurotoxic injury an amount sufficient to reduce said effects of a compound having an indolactam V ring system, wherein said compound has a formula ##STR6## wherein:
- U is H or methyl;
- V is H or an alkyl group;
- W is H, an alkyl group, or an alkyl group substituted with a hydroxyl group:
- and
- X and Y independently represent hydrogen or a hydrophobic substituent containing up to 15 carbon atoms, with the proviso that said hydrophobic substituent is not a hydrocarbon substituent and X and Y are not simultaneously hydrogen.
3 more elements
Dependencies are inferred from the claim text.