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US 5,292,760 AGranted
4-heteroaryl-1,3-benzodiazepines and 2-substituted-.alpha.-(heteroaryl)benzeneethanamines
AssigneeHoechst-Roussel Pharmaceuticals Inc.
InventorsLawrence L. Martin, Joseph F. Payack, Salvatore M. Brucato
Life of this patent
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Abstract
Novel 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines, intermediates, processes for the preparation thereof, and methods for treating depression, inhibiting convulsions and treating anxiety utilizing compounds and compositions thereof are disclosed.
Claims72
A compound of the formula:
- wherein Ar is selected from the group consisting of ##STR22## wherein R.sup.2 is hydrogen, loweralkyl or loweralkanoyl, Y is selected from the group consisting of halogen, hydroxyl, loweralkyl, loweralkoxy and trifluoromethyl, n is an integer having a value from 0 to 3 inclusive, p is an integer having a value of 0 or 1, and q is an integer having a value from 0 to 4 inclusive;
- X is selected from the group consisting of halogen, hydroxyl, nitro, loweralkyl, loweralkoxy, and trifluoromethyl;
- m is an integer having a value from 0 to 3 inclusive;
- R.sup.1 is selected from the group consisting of hydrogen, loweralkyl, and aralkyl;
- R.sup.3 is hydroxy, loweralkoxy, amino, loweralkylamino, diloweralkylamino, nitro, or NR.sup.6 C(O)R.sup.4 wherein R.sup.4 and R.sup.6 are independently hydrogen or loweralkyl;
- and R.sup.5 is hydrogen, loweralkyl or C(O)R.sup.7 where R.sup.7 is hydrogen or loweralkyl;
- wherein for each value of m, n, p or q each X or Y may be the same or different;
- the geometrical isomers, optical antipodes or pharmaceutically acceptable acid addition salts thereof.
5 more elements
A compound of the formula:
- ##STR26## wherein X is halogen, m is zero or 1, and Ar is ##STR27##
Dependencies are inferred from the claim text.