Sulfonamide derivatives

Sulfonamide derivatives of the formula (I) or pharmacologically acceptable salts thereof:

• ##STR143## wherein:
• R.sup.1 represents a hydrogen atom, halogen atom, lower alkyl group, lower alkoxy group, hydroxyl group, nitro group, phenoxy group, cyano group, acetyl group, amino group or a protected amino group, R.sup.2 and R.sup.3 may be the same or different from each other and each represent a hydrogen atom, halogen atom, lower alkyl group or lower alkoxy group, R.sup.4 and R.sup.7 may be the same or different from each other and each represents a hydrogen atom or a lower alkyl group, R.sup.5 and R.sup.6 may be the same or different from each other and each represents a hydrogen atom, halogen atom, lower alkoxy group, amino group or amino group substituted with a lower alkyl or a phenyl group, A is .dbd.CH--, B is .dbd.N--, and E is a pyridyl group or a pyridyl group having from 1 to 3 substituents, said substituents being the same or different from one another and selected from the group consisting of a halogen atom, lower alkyl group, lower alkoxy group, hydroxyl group, protected hydroxyl group, carboxyl group, esterified carboxyl group, amidated carboxyl group, lower alkylthio group and phenoxy group.