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AssigneeHoechst Aktiengesellschaft
InventorsHeinrich C. Englert, Hans-Jochen Lang, Wolfgang Linz, Bernward Scholkens, Wolfgang Scholz
Estimating the term…
Benzoylguanidines of the formula I ##STR1## where R(1) or R(2) is equal to R(6)--S(O).sub.n -- or R(7)R(8)N--O.sub.2 S-- and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br, I, alkyl, alkoxy or phenoxy, R(6)--S(O).sub.n or R(7)R(8)N-- and R(6) is equal to alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl, R(7) and R(8) are equal to alkyl or phenylalkyl or phenyl, and in which R(7) and R(8) may also together be a C.sub.4 --C.sub.7 chain, and in which R(7) and R(8), together with the nitrogen atom to which they are bonded, may be a dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system, and where R(3), R(4) and R(5) are equal to hydrogen or alkyl, or R(3) and R(4) are together an alkylene chain or R(4) and R(4) are together an alkylene chain, and where n is equal to zero, 1 or 2 and their pharmaceutically tolerable salts are outstanding antiarrhythmics.
A benzoylguanidine of formula I ##STR8## in which one of R(1) and R(2) is R(6)--S(O).sub.n -- or ##STR9## and the other of R(1) and R(2) is H, F, Cl, Br, I, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, phenoxy which is unsubstituted or carries one to three substituents selected from fluorine, chlorine, methyl or methoxy, R(6)--S(O).sub.n or ##STR10## in which R(6) is C.sub.1 -C.sub.6 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl which is unsubstituted or carries one to three substituents selected from fluorine, chlorine, methyl or methoxy;
Dependencies are inferred from the claim text.