Therapeutic agents

A method of lowering the activity of an .alpha..sub.2 -plasmin inhibitor which comprises administering to a human or an animal in need thereof an effective amount sufficient to lower the activity of an .alpha..sub.2 -plasmin inhibitor of a compound selected from the group consisting of:

• a. A compound of the formula ##STR3## ,a pharmaceutically acceptable acid addition salt thereof or a quaternary salt thereof wherein R.sup.1 is hydrogen, alkyl of 1 to 10 carbon atoms, carboxyalkyl of 1 to 10 carbon atoms in the alkyl moiety, lower alkyloxycarbonylalkyl of 1 to 10 carbon atoms in the alkyl moiety, hydroxyalkyl of 1 to 10 carbon atoms in the alkyl moiety, cycloalkyl lower alkyl wherein the cycloalkyl moiety is of 3 to 7 carbon atoms, aryl lower alkyl, aryloxy lower alkyl, alkenyl of 2 to 10 carbon atoms or arylalkenyl of 2 to 10 carbon atoms in the alkenyl moiety.