Substituted pyrroles

A compound of the formula ##STR9## wherein R.sup.1 and R.sup.3 together form a bond and R.sup.2 is hydrogen or R.sup.1 and R.sup.2 together form a bond and R.sup.3 is hydrogen;

• R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each independently are hydrogen, halogen, C.sub.1-7 alkyl, halo C.sub.1-7 alkyl, C.sub.1-7 alkoxy, nitro, amino, C.sub.1-7 alkanoylamino, aroylamino, C.sub.1-7 alkylthio or C.sub.1-7 alkylsulfonyl;
• R.sup.8 is hydrogen, C.sub.1-7 alkyl or aryl-C.sub.1-7 -alkyl;
• m is 0-2 and n is 1-3, with the proviso that the sum of m and n is 1-3;
• p is 0-4 and q is 0-4, with the proviso that the sum of p and q is 2-4 when X' is --N(R.sup.9')--, that the sum of p and q is 1-5 when X' is --CHN(R.sup.10', .sup.11'")-- and R.sup.1 and R.sup.2 together form a bond, that the sum of p and q is 0-4 when X' is --CHN(R.sup.10',R.sup.11')-- and R.sup.1 and R.sup.3 together form a bond, and that p is 1-4 when X' is --N(R.sup.9')--, R.sup.1 and R.sup.3 together represent a bond and m is O, X' is --N(R.sup.9')-- or --CHN(R.sup.10',R.sup.11')-- in which R.sup.9', R.sup.10' and R.sup.11' each are hydrogen, C.sub.1-7 alkyl, aryl-C.sub.1-7 -alkyl, C.sub.1-7 alkanoyl, alkoxycarbonyl or aryloxycarbonyl.

A pharmaceutical composition comprising an effective amount of a compound of the formula ##STR10## wherein R.sup.1 and R.sup.3 together form a bond and R.sup.2 is hydrogen or R.sup.1 and R.sup.2 together form a bond and R.sup.3 is hydrogen;

• R.sup.4, R.sup.5, R.sup.6 and R.sup.7 each independently are hydrogen, halogen, C.sub.1-7 alkyl, halo C.sub.1-7 alkyl, C.sub.1-7 alkoxy, nitro, amino, C.sub.1-7 alkanoylamino, aroylamino, C.sub.1-7 alkylthio or C.sub.1-7 alkylsulfonyl;
• R.sup.8 is hydrogen, C.sub.1-7 alkyl or aryl C.sub.1-7 alkyl;
• X is --N(R.sup.9)-- or --CHN(R.sup.10,R.sup.11)-- in which R.sup.9, R.sup.10 and R.sup.11 each are hydrogen, C.sub.1-7 alkyl, aryl C.sub.1-7 alkyl or C.sub.1-7 alkanoyl;
• m is 0-2 and n is 1-3, with the proviso that the sum of m and n is 1-3;
• p is 0-4 and q is 0-4, with the proviso that the sum of p and q is 2-4 when X is --N(R.sup.9)--, that the sum of p and q is 1-5 when X is --CHN(R.sup.10,R.sup.11)-- and R.sup.1 and R.sup.2 together form a bond, that the sum of p and q is 0-4 when X is --CHN(R.sup.10,R.sup.11)-- and R.sup.1 and R.sup.3 together form a bond, and that p is 1-4 when X is --N(R.sup.9)--, R.sup.1 and R.sup.3 together represent a bond and m is 0, or a pharmaceutically acceptable salt of an acidic compound of formula I with a base or a basic compound of formula I with an acid, and a therapeutically inert carrier.