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US 5,292,746 AGranted
Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsAlbert A. Carr, Craig E. Thomas, Ronald C. Bernotas, George Ku
Life of this patent
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Abstract
The present invention is directed to a new class of cyclic nitrones and their use as spin trapping agents.
Claims34
A cyclic nitrone of the formula:
- ##STR35## in which R.sub.1 and R.sub.2 are each independently represented by a C.sub.1-3 alkyl or R.sub.1 and R.sub.2 together form a C.sub.2-7 alkylene chain;
- n is represented by an integer from 0-2;
- and R.sub.3 is represented by a substituent selected from the group consisting of hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, --CF.sub.3, --OCF.sub.3 and --OH.
Dependencies are inferred from the claim text.