Anti-virally active pyridazinamines

An anti-rhinoviral composition consisting essentially of an inert carrier and as an active ingredient an anti-rhinovirally effective amount of a compound of the formula:

• ##STR195## a pharmaceutically acceptable acid-addition salt or a stereoisomeric form or a tautomeric form thereof, wherein:
• R.sup.1 is a member selected from the group consisting of hydrogen, halo, 1H-imidazol-1-yl, lower alkyloxy, aryloxy, aryllower alkyloxy, lower alkylthio, arylthio, hydroxy, mercapto, amino, lower alkylsulfinyl, lower alkylsulfonyl, cyano, lower alkyloxycarbonyl, lower alkylcarbonyl, and lower alkyl;
• and
• A.sup.2 is a bivalent radical of the formula:
• --C.sub.m H.sub.2m --C(R.sup.5)(R.sup.6)--C.sub.n H.sub.2n --(c);
• or
• --C.sub.m-1 H.sub.2(m-1) --C(R.sup.7).dbd.C(R.sup.8)--C.sub.n H.sub.2n --(d);
• wherein one of the hydrogen atoms within the radical C.sub.m H.sub.2m, C.sub.m-1 H.sub.2(m-1), or C.sub.n H.sub.2n may be replaced by lower alkyl or aryl;
• m is the integer 1 or 2 and n is the integer 2;
• R.sup.5 is hydrogen, aryl, arylamino, (aryl)(lower alkyl)amino, hydroxy, or indolyl;
• R.sup.6 is hydrogen, aryl, arylcarbonyl, or (arylcarbonyl)lower alkyl;
• and
• R.sup.7 and R.sup.8 are, each independently, members selected from the group consisting of hydrogen, lower alkyl, aryl, aryllower alkyl, and pyridinyl;
• wherein aryl is phenyl, being optionally substituted with up to 3 substituents, each independently selected from the group consisting of halo, lower alkyl, trifluoromethyl, nitro, amino, lower alkyloxy, hydroxy and lower alkyloxycarbonyl;
• thienyl;
• and naphthalenyl,
• provided that when A.sup.2 is a radical of formula (c) and one of R.sup.5 and R.sup.6 is hydrogen, then the other of R.sup.5 and R.sup.6 cannot be hydrogen, hydroxy, or lower alkyl.