N,N'-bis(sulfonamido)-2-amino-4-iminonaphthalen-1-ones and N,N'-bis(amido)-2-amino-4-iminonaphthalen-1-ones
AssigneeSphinx Pharmaceuticals Corporation
InventorJean M. Defauw
Life of this patent
Estimating the term…
Abstract
N,N'-Bis(sulfonamido)-2-amino-4-iminonaphthalen-1-ones and N,N'-Bis(amido)-2-amino-4-iminonaphthalen-1-ones are disclosed. Methods of inhibiting protein kinase C activity which comprises contacting protein kinase C with an effective amount of an N,N'-Bis(sulfonamido)-2-amino-4-iminonaphthalen-1-one or an N,N'-Bis(amido)-2-amino-4-iminonaphthalen-1-one are disclosed. Methods of treating an animal that is suspected of suffering from inflammatory, cardiovascular and/or neoplastic diseases which comprises administering an effective amount of an N,N'-Bis(sulfonamido)-2-amino-4-iminonaphthalen-1-one or an N,N'-Bis(amido)-2-amino-4-iminonaphthalen-1-one are disclosed.
Claims26
A compound having the formula:
- ##STR8## wherein:
- a is:
- a phenyl or naphthyl ring system;
- L is:
- SO.sub.2 CO;
- R.sup.1 -R.sup.3 are each, independently:
- hydrogen, alkyl, aryl, alkylaryl, arylalkyl, or cycloalkyl;
- R.sup.4 -R.sup.8 are each, independently:
- hydrogen, alkyl, aryl, alkylaryl, arylalkyl, halogen, nitro, amino, acylamino, hydroxy, carboxyl, alkoxy, aryloxy, thioalkoxyl, alkylthio, arylthio or a fused aromatic ring;
- B is:
- hydrogen, aryl, arylalkyl, alkylaryl, C.sub.3 -C.sub.8 cycloalkyl;
- C.sub.2-C.sub.20 alkyl, C.sub.2 -C.sub.20 alkenyl, C.sub.2 -C.sub.20 alkynyl, acyl or substituted thereof;
- or pyrrolyl, imidazolyl, triazolyl, tetrazolyl, furanyl, thiophenyl, isoxazolyl, isothiazolyl, oxazolyl, 1,2,4-thiadiazolyl, pyridazinyl, pyridinyl, pyrimidinyl, pyrazinyl, quinoxalinyl, quinolinyl, isoquinolinyl, wherein all rings may be substituted;
- m is:
- 0-1;
- and
- n is:
- 0-6;
- wherein when m is 1,
- R.sup.9 and R.sup.10 are each, independently:
- hydrogen, alkyl, aryl, alkylaryl, arylalkyl or cycloalkyl groups;
- or pharmaceutically acceptable salts of said compound.
Dependencies are inferred from the claim text.