Loading patent…
AssigneeEisai Co., Ltd.
InventorsHachiro Sugimoto, Masahiro Yonaga, Norio Karibe, Youichi Iimura, Satoshi Nagato, Atsushi Sasaki, Yoshiharu Yamanishi, Hiroo Ogura, Takashi Kosasa, Kumi Uchikoshi, Kiyomi Yamatsu
Estimating the term…
The cyclic amide derivative is defined by the formula (I) or a salt thereof: R1--(CH2)n-z in which R1 is a group derived from a cyclic amide compound, substituted or unsubstituted, n is zero or an integer of 1 to 10 and Z is ##STR1## R2 being an aryl, a substituted aryl, a cycloalkyl or a heterocyclic group, m being an integer of 1 to 6, R3 being hydrogen or a lower alkyl, R4 being an aryl or a substituted aryl, a cycloalkyl or a heterocyclic group, p being an integer of 1 to 6, provided that the cyclic amide compound is quinazoline-on or quinazoline-dion, R2 and R4 are neither aryl nor substituted aryl. The cyclic amide compound is pharmacologically effective to prevent and treat diseases due to insufficiency of the central choline functions.
A cyclic amide derivative having the formula wherein R.sup.1 is ##STR104## wherein R.sup.5 is hydrogen, a lower alkyl, a lower alkoxy, a halogen, an amino or nitro and l is an integer of 1 to 4;p n is an integer of 1 to 10 and Z is ##STR105## wherein R.sup.2 is an aryl selected from the group consisting of phenyl and naphthyl, cycloalkyl selected from the group consisting of cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl, a pyridyl group, a 1,3-dioxolan-2-yl group, a furyl group, a thienyl group or a tetrahydrofuryl group;
A cyclic amide derivative having the formula wherein R.sup.1 is
A compound having the formula ##STR107## or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.