Methods of treatment using methotrexate compositions
AssigneeChemex Pharmaceuticals, Inc.
InventorBernard Loev
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Abstract
Compositions containing metal salts of methotrexate and methotrexate derivatives or analogs are disclosed. Such compositions comprise a metal salt, preferably a zinc salt, of methotrexate or a methotrexate derivative or analog and a carrier suitable for delivering the metal salt in the desired pharmacological form. Methods of treatment are also disclosed in which such compositions are topically applied or orally or parenterally administered to a patient. The metal salt is present in the treating composition in an amount sufficient to produce the desired therapeutic effect upon application or administration.
Claims15
A method of treating a hyperproliferative disorder of the skin comprising orally or parenterally administering or topically applying a composition to a patient, said composition comprising a pharmaceutically suitable carrier and a therapeutically effective amount of a compound of the general formula (I), (II), (III) or (IV):
- ##STR3## wherein n is 0 or an integer from 1 to 4, X.sup.- is an anion, R.sub.2 is hydrogen or an aliphatic, aromatic or arylalkyl group, and R.sub.1 is of the general formula (V):
- ##STR4## wherein R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are hydrogen or an alkyl group of 1 to 5 carbons.
A method of treating a hyperproliferative disorder of the skin comprising orally or parenterally administering or topically applying a composition to a patient, said composition comprising a pharmaceutically suitable carrier and a therapeutically effective amount of a compound of the general formula (I), (II), (III) or (IV):
- ##STR5## wherein n is 0 or an integer from 1 to 4, M.sup.2+ is a divalent metal cation, X.sup.- is an anion, R.sub.2 is hydrogen or an aliphatic, aromatic or arylalkyl group, and R.sub.1 is of the general formula ##STR6## wherein R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are hydrogen or an alkyl group of 1 to 5 carbons.
Dependencies are inferred from the claim text.