US 5,292,729 A · II-bond aromatic vitamin chelates

Abstract

Vitamin and mineral absorption in warm-blooded animals is promoted by means of a class of vitamin chelates where at least one of the bonds between the metal ion and the vitamin ligand is formed between the ion and an electron rich .pi.-cloud of an aromatic ring of the water soluble vitamin. The chelate, containing a total of from one to three ligands, may contain from one up to three vitamin ligands which form a .pi.-bond with the mineral and, when present, one or two amino acid, dipeptide or tripeptide ligands. The mineral is selected from the group consisting of Fe, Cu, Zn, Mg, Mn and Ca. The water soluble vitamin ligand is preferably a residue of nicotinamide, nicotinic acid, pyridoxine, thiamine, riboflavin and folic acid. The amino acid may be any of the naturally occurring .alpha.-amino acids such as glycine. The .pi.-bond vitamin chelates are absorbed more readily from both the gastric and intestinal areas of the GI tract than vitamins or minerals administered separately or as mixtures.

Claims50

Dependent claims

A vitamin mineral chelate having at least one .pi.-cloud bond formed between the .pi. cloud of an aromatic moiety of a water soluble vitamin and the mineral, said chelate having the formula:

##STR12## wherein a is an integer of 0, 1 or 2, b is an integer of 1, 2 or 3, with the proviso that the sum of a and b does not exceed 3, the combination of X, Y and .circleincircle.-Z is the residue of said water vitamin wherein X is a member selected from the group consisting of OH, SH and NH.sub.2, Y is a member selected from the group consisting of CH.sub.2, CH.sub.2 CH.sub.2, and C(O), .circleincircle. is the aromatic ring of said water soluble vitamin and Z is the remainder of the residue of said water soluble vitamin not defined by X, Y and .circleincircle. with the proviso that .circleincircle., Y and X are configured to form a five or six membered ring structure when bonded to M;
R is the residue of any naturally occurring .alpha.-amino acid, R' is a member selected from the group consisting of H and [C(O)CHRNH].sub.e H where e is an integer of 1 or 2, and M is a metal ion selected from the group consisting of Fe, Cu, Mn, Zn, Ca and Mg.

Dependencies are inferred from the claim text.

II-bond aromatic vitamin chelates

Life of this patent

II-bond aromatic vitamin chelates

Life of this patent

Abstract

Claims50