24-Oxa derivatives in the vitamin D series
AssigneeSchering Corporation
InventorsGunter Neef, Gerald Kirsch, Andreas Steinmeyer, Katica Schwarz, Matthias Brautigam, R. Thieroff-Ekerdt, Petra Rach
Life of this patent
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Abstract
New 24-oxa derivatives in the vitamin D series of general formula I are described in which R.sup.1, R.sup.2 and R.sup.5, independently of one another, mean a hydrogen atom or an acyl group with 1 to 9 carbon atoms, R.sup.3 means a hydrogen atom or a linear or branched alkyl group with 1 to 4 carbon atoms and R.sup.4 means a hydrogen atom each or a linear or branched alkyl group each with 1 to 4 carbon atoms. Pharmaceutical preparations which contain these compounds are also disclosed.
Claims7
24-Oxa derivatives in the vitamin D series of general formula I ##STR9## in which R.sup.1, R.sup.2 and R.sup.5, independently of one another, are a hydrogen atom or an acyl group with 1 to 9 carbon atoms,
- R.sup.3 is a hydrogen atom or a linear or branched alkyl group with 1 to 4 carbon atoms and
- R.sup.4 is a hydrogen atom or a linear or branched alkyl group having 1 to 4 carbon atoms.
A compound which is 1.alpha.,25-dihydroxy-24-oxa-24-homo-cholecalciferol,
- 1.alpha.,25-dihydroxy-26,27-dimethyl-24-oxa-24-homo-cholecalciferol,
- 26,27-diethyl-1.alpha.,25-dihydroxy-24-oxa-24-homo-cholecalciferol,
- 1.alpha.,25-dihydroxy-24-oxa-26,27-di-n-propyl-24-homo-cholecalciferol,
- 1.alpha.,26-dihydroxy-24-oxa-cholecalciferol, or
- 1.alpha.,26-dihydroxy-27-methyl-24-oxa-cholecalciferol.
Dependencies are inferred from the claim text.