Hyperosmotic solutions for isonatremic resuscitation
AssigneeThe Regents of the University of California
InventorsGeorge C. Kramer, Azad Sheikh, Robert A. Gunther
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Abstract
The invention provides a physiologically acceptable solution for treating circulatory shock in mammals which is hyperosmotic as compared to blood plasma. The solution contains a reabsorbable solute and sodium salt in a concentration having an osmolarity in excess of about 1000 mOsms. The physiologically acceptable solution can be easily administered by rapid infusion of 4-6 ml/kg body weight and results in rapid normalization of circulatory function.
Claims7
A method of preventing or treating hypodynamic circulatory shock in a mammal, comprising the step of administering to said mammal in a condition or potentially in a condition of shock, a therapeutically effective dose of a physiologically acceptable solution, said solution comprising reabsorbable solutes and a sodium salt, said reabsorbable solutes consisting essentially of at least one sugar or a derivative of a sugar and at least one amino acid or a derivative of an amino acid and said solution having an osmolarity in excess of 1000 mOsms.
Dependencies are inferred from the claim text.