Antibacterial antiplaque anticalculus oral composition
AssigneeColgate-Palmolive Company
InventorsAbdul Gaffar, Nuran Nabi, John Afflitto, Orum Stringer
Life of this patent
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Abstract
An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncationic antibacterial agent such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Triclosan). Antiplaque effectiveness is optimized by the presence of an antibacterial-enhancing agent which enhances delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
Claims33
An oral composition comprising an orally acceptable aqueous-humectant dentifrice or toothpaste vehicle, a dentally acceptable water-insoluble polishing agent, a water-soluble or swellable anti-bacterial enhancing agent which is effective to enhance the anti-bacterial effect of a substantially water-insoluble non-cationic antibacterial agent, which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group, wherein said delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment adherence or bonding of said antibacterial agent on oral tooth and gum surfaces, and an effective anticalculus amount of a linear molecularly dehydrated polyphosphate, wherein the polyphosphate is present in amount such that the weight ratio of polyphosphate ion to anti-bacterial agent ranges from in excess of 0.72:1 to less than 4:1 said dentifrice or toothpaste having an optimized antiplaque effectiveness by presentation of said non-cationic antibacterial agent in a macroemulsion formed by adding said "A.E.A", or antibacterial enhancing agent incrementally, to a clear solution micro-emulsion of said antibacterial agent typically dissolved in admixtures of humectant and surface active agent, until the solution becomes cloudy, and may be characterized as a macroemulsion.
An oral composition comprising an orally acceptable aqueous-humectant dentifrice or toothpaste vehicle, a dentally acceptable water-insoluble polishing agent, a water-insoluble or swellable anti-bacterial-enhancing agent which is effective to enhance the anti-bacterial effect of a substantially water-insoluble non-cationic antibacterial agent, which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group, wherein said delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces, the said composition containing a mixture of potassium and sodium salts at least one of which is present in an effective anticalculus amount as a polyphosphate anticalculus agent, the ratio of potassium to sodium in the said composition being in the range of up to less than 3:1 said dentifrice or toothpaste having an optimized antiplaque effectiveness by presentation of said non-cationic antibacterial agent in a macroemulsion formed by adding said "A.E.A", or antibacterial enhancing agent incrementally, to a clear solution micro-emulsion of said antibacterial agent typically dissolved in admixtures of humectant and surface active agent, until the solution becomes cloudy, and may be characterized as a macroemulsion.
An oral composition comprising an orally acceptable aqueous-humectant dentifrice or toothpaste vehicle, a dentally acceptable water-insoluble polishing agent, substantially water insoluble non-cationic anti-bacterial agent in an amount which retards the oral growth of plaque of from 0.25% to less than 0.5% by weight and a water-soluble or swellable anti-bacterial-enhancing agent which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group, wherein said delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces said dentifrice or toothpaste having an optimized antiplaque effectiveness by presentation of said non-cationic antibacterial agent in a macroemulsion formed by adding said "A.E.A", or antibacterial enhancing agent incrementally, to a clear solution micro-emulsion of said antibacterial agent typically dissolved in admixtures of humectant and surface active agent, until the solution becomes cloudy, and may be characterized as a macroemulsion.
An oral composition comprising an orally acceptable aqueous-humectant dentifrice or toothpaste vehicle, a dentally acceptable water-insoluble polishing agent, a substantially water insoluble non-cationic anti-bacterial agent, in an amount which retards the oral growth of plaque of from 0.25% to 0.35% and a water-soluble or swellable antibacterial-enhancing agent which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group, wherein said delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces said dentifrice or toothpaste having an optimized antiplaque effectiveness by presentation of said non-cationic antibacterial agent in a macroemulsion formed by adding said "A.E.A", or antibacterial enhancing agent incrementally, to a clear solution micro-emulsion of said antibacterial agent typically dissolved in admixtures of humectant and surface active agent, until the solution becomes cloudy, and may be characterized as a macroemulsion.
An oral composition comprising an orally acceptable aqueous-humectant dentifrice or toothpaste vehicle, a dentally acceptable water-insoluble siliceous polishing agent, about 0.25% to less than 0.5% by weight 9 f a substantially water-insoluble non-cationic anti-bacterial agent to retard oral growth of plaque and a water-soluble or swellable anti-bacterial-enhancing agent which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group, wherein said delivery-enhancing group, enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces said dentifrice or toothpaste having an optimized antiplaque effectiveness by presentation of said non-cationic antibacterial agent in a macroemulsion formed by adding said "A.E.A", or antibacterial enhancing agent incrementally, to a clear solution micro-emulsion of said antibacterial agent typically dissolved in admixtures of humectant and surface active agent, until the solution becomes cloudy, and may be characterized as a macroemulsion.
An oral composition comprising in an orally acceptable aqueous humectant dentifrice or toothpaste vehicle, a dentally acceptable water-insoluble polishing agent, an effective anticalculus amount of linear molecularly dehydrated polyphosphate salt anticalculus agent present in a mixture of sodium and potassium salts wherein the ratio of potassium to sodium in said composition is up to less than 3:1, and effective antiplaque amount to retard the oral growth of plaque of a substantially water insoluble non-cationic antibacterial agent and about 0.05-4% by weight of an antibacterial-enhancing agent which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group, wherein said delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces said dentifrice or toothpaste having an optimized antiplaque effectiveness by presentation of said non-cationic antibacterial agent in a macroemulsion formed by adding said "A.E.A", or antibacterial enhancing agent incrementally, to a clear solution micro-emulsion of said antibacterial agent typically dissolved in admixtures of humectant and surface active agent, until the solution becomes cloudy, and may be characterized as a macroemulsion.
An oral composition comprising an orally acceptable aqueous-humectant dentifrice or toothpaste vehicle, a dentally acceptable water-insoluble polishing agent, an effective amount of a linear, molecularly dehydrated polyphosphate, an effective amount to retard the growth of plaque in the range of about 0.01-5% by weight of a substantially water insoluble non-cationic antibacterial agent and about 0.05-4% by weight of water-soluble or swellable antibacterial-enhancing agent which contains at least one delivery-enhancing functional group and at least one organic retention-enhancing group, wherein said delivery-enhancing group enhances delivery of said antibacterial agent to oral tooth and gum surfaces and said retention-enhancing group enhances attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces, wherein said polyphosphate is present in an amount wherein the weight ratio of said antibacterial enhancing agent to said polyphosphate ion ranges from about 1:6 to about 2.7:1 said dentifrice or toothpaste having an optimized antiplaque effectiveness by presentation of said non-cationic antibacterial agent in a macroemulsion formed by adding said "A.E.A", or antibacterial enhancing agent incrementally, to a clear solution micro-emulsion of said antibacterial agent typically dissolved in admixtures of humectant and surface active agent, until the solution becomes cloudy, and may be characterized as a macro-emulsion.
An oral composition comprising in an orally acceptable aqueous humectant dentifrice or toothpaste vehicle, a dentally acceptable water-insoluble polishing agent, an effective anticalculus amount of a linear molecularly dehydrated polyphosphate, an effective antiplaque amount of a substantially water insoluble noncationic antibacterial agent, in the range of about 0.01-5% by weight, and about 0.05-4% by weight of an anionic copolymer of maleic acid or anhydride with another ethylenically unsaturated polymerizable monomer, which copolymer enhances delivery and attachment, adherence or bonding of said antibacterial agent on oral tooth and gum surfaces, wherein said polyphosphate is present in amount wherein the weight ratio of said antibacterial enhancing agent to said polyphosphate ranges from about 1:6 to about 2.7:1 said dentifrice or toothpaste having an optimized antiplaque effectiveness by presentation of said non-cationic antibacterial agent in a macroemulsion formed by adding said "A.E.A", or antibacterial enhancing agent incrementally, to a clear solution micro-emulsion of said antibacterial agent typically dissolved in admixtures of humectant and surface active agent, until the solution becomes cloudy, and may be characterized as a macroemulsion.
Dependencies are inferred from the claim text.