Modified polypeptides of IL-1.alpha.
AssigneeDainippon Pharmaceutical Co., Ltd.
InventorsMichiko Yamayoshi, Hitoshi Kawashima, Junichi Yamagishi, Hirotada Kotani, Ryuji Furuta, Toshikazu Fukui
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Abstract
Novel polypeptides having a modified amino acid sequence of human interleukin 1.alpha. polypeptides in which a certain amino acid residue(s) in said amino acid sequence is(are) exchanged for other amino acid residue(s). Said polypeptides having no capacity of induction of production of prostaglandin E.sub.2 while maintaining other biological activities of human interleukin 1 such as activation of lymphocyte and being expected to be useful as a medicament.
Claims3
A modified human interleukin 1.alpha. polypeptide having an amino acid sequence of the following formula [I]:
- ##STR6## in which W means Ser, X means Asn, and Y means Tyr, Phe, Lys, or Arg.
A modified human interleukin 1.alpha. polypeptide having the sequence ##STR7## in which X is Asn or Asp and Y is Tyr.
Dependencies are inferred from the claim text.