Phenoxyalkylcarboxylic acid derivatives and process of preparing the same
AssigneeKyorin Pharmaceutical Co., Ltd.
InventorsMitsuo Ohashi, Toshio Tanaka, Norihisa Ishikawa, Tetsuya Kishi
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Abstract
Phenoxyalkylcarboxylic acid derivatives represented by the following formula (I) ##STR1## having a strong and selective leukotriene antagonistic action and useful for prophylaxis and therapy of allergic diseases as asthma and processes of preparing the same.
Claims5
A phenoxyalkylcarboxylic acid derivative or alkali salt thereof represented by a formula (1) ##STR10## wherein R.sup.1 denotes a hydrogen atom, methyl group or ethyl group.
A method of preparing a compound of the formula (1) ##STR14## characterized in that a compound represented by a formula (4) ##STR15## wherein Y denotes a halogen atom and R.sup.1 denotes a hydrogen atom, methyl group or ethyl group is allowed to react with a compound represented by formula (5) ##STR16## and, if desired, subjected to hydrolysis.
A method of preparing a compound represented by a formula (7) ##STR17## wherein R denotes a hydrogen atom or halogenopropyl group and R.sup.1 denotes a hydrogen atom, methyl group or ethyl group characterized in that a compound represented by a formula (6) ##STR18## wherein R denotes a hydrogen atom or halogenopropyl group and R.sup.1 denotes a hydrogen atom, methyl group or ethyl group is subjected to hydrogenation.
An anti-allergenic composition comprising a pharmaceutically effective amount of a phenoxyalkylcarboxylic acid derivative of the formula;
- ##STR19## wherein R.sup.1 is hydrogen, methyl or ethyl, or an alkali salt thereof in combination with a non-allergenic pharmaceutical carrier.
Dependencies are inferred from the claim text.