3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents

A compound of the formula I ##STR28## and a pharmaceutically acceptable base or acid addition salt thereof, wherein

• Me is methyl;
• X is O;
• R.sub.8 is hydrogen or methyl;
• Y is ##STR29## n is 1, 2 or 3;
• m is 1 to 5;
• R.sub.1 and R.sub.2 are independently H, lower alkyl, phenylalkyl, in which phenyl is unsubstituted or substituted as defined below, or (CH.sub.2).sub.n NR.sub.6 R.sub.7 ;
• R.sub.3 is H, lower alkyl, phenyl or phenyl substituted by one, two or three substituents of one or more of each of alkyl of one to four carbons, OR.sub.4, SR.sub.4, ##STR30## hydroxymethyl, NR.sub.6 R.sub.7, nitro or halogen;
• R.sub.4 is H or lower alkyl;
• R.sub.5 is lower alkyl, phenyl or phenyl substituted as defined above, or CF.sub.3 ;
• R.sub.6 is H or lower alkyl;
• R.sub.7 is lower alkyl;
• Z is O, S, NH, NCN;
• and
• W is CO.sub.2 R.sub.7 wherein R.sub.7 is as defined above, (CH.sub.2).sub.m COOH, ##STR31## (CH.sub.2).sub.m OH, or C(CH.sub.2 OH).sub.3.