Substituted urea compound and use
AssigneeNovo Nordisk N/A
InventorJohn B. Hansen
Life of this patent
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Abstract
New substituted urea compounds of formula I, or a pharmaceutically acceptable salt thereof: ##STR1## wherein A is ##STR2## wherein R.sup.3 is an oxadiazol, substituted with C.sub.1-8 -alkyl, C.sub.2-8 -alkenyl, C.sub.2-8 alkynyl, C.sub.3-7 cycloalkyl, benzyl, phenyl, C.sub.1-6 -alkoxy, C.sub.1-6 -alkylthio, amino or alkylamino; R.sup.2 is --H or lower alkyl; X is O or S; and R.sup.1 is a group of formula II, III, IV or V ##STR3## where n is 2 or 3, P is 1 or 2, q is 1 to 3, r is 1-3 and R.sup.4 and R.sup.5 are H,C.sub.1-7 alkyl or C.sub.3-6 cycloalkyl; and N-oxides thereof. The compounds are useful in pharmaceutical preparations for treating psychotic disorders, nausea and vomiting.
Claims10
A compound of formula I:
- ##STR8## wherein A is ##STR9## wherein R.sup.3 is a 1,2,4-oxadiazole substituted with C.sub.1-8 -alkyl, C.sub.2-8 -alkenyl, C.sub.2-8 -alkynyl, C.sub.3-7 -cycloalkyl, benzyl, phenyl, C.sub.1-6 -alkoxy, C.sub.1-6 -alkylthio or amino;
- R.sup.2 is H or lower alkyl;
- X is O or S;
- and
- R.sup.1 is a group of formula III ##STR10## wherein p is 1 and q is 2;
- or
- an N-methylated ammonium derivative thereof.
Dependencies are inferred from the claim text.