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US 5,290,788 AGranted
Indole derivatives as antiallergy and antiinflammatory agents
AssigneePfizer Inc.
InventorsRodney W. Stevens, Hiromasa Morita, Masami Nakane
Life of this patent
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Abstract
Alkoxy substituted indole derivatives as inhibitors of lipoxygenase and useful as antiallergy and antiinflammatory agents.
Claims15
A compound of the formula ##STR4## and the pharmaceutically acceptable salts thereof wherein R.sub.1 is quinoylyl or pyridyl;
- m is an integer of 1 to 2;
- Y.sub.1 is hydrogen, or alkyl having one to four carbon atoms;
- Y.sub.2 is hydrogen, alkyl having one to four carbon atoms, pyridylvinylene, benzoyl or substituted benzoyl where said substituent is methyl, methoxy, chloro, fluoro or trifluoromethyl, benzyl or substituted benzyl wherein said substituent is methyl, methoxy, chloro, fluoro or trifluoromethyl;
- A is --CH.sub.2 -- or --C(O)--;
- n is an integer of 0 to 3;
- and X is hydrogen, alkyl having one to three carbon atoms, pyridyl, hydroxy, thienyl, carboxy, alkoxycarbonyl of two to four carbon atoms, amino, benzyloxycarbonylamino, phenyl or substituted phenyl wherein aid substituent is methyl, carboxy, alkoycarbonyl of two to four carbon atoms, methoxy, fluoro, chloro or trifluoromethyl with the proviso that when A is --C(O)--, n is 1 and when n is 0, X is hydrogen.
3 more elements
Dependencies are inferred from the claim text.