Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
AssigneeAmerican Cyanamid Company
InventorsAranapakam Venkatesan, Jeremy I. Levin
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Abstract
Novel quinazolinone compounds of the formula: ##STR1## wherein R.sup.5, R.sup.6, R.sup.7, R.sup.8, R and X are defined in the specification, which have angiotensin II (AII) antagonizing activity, intermediates useful in the preparation of the compounds, methods of producing and using the compounds to alleviate angiotensin induced hypertension and treat congestive heart failure in mammals.
Claims5
The compound 2-butyl-6-(1-methoxy-1-methylethyl)-3-[[2'-(1H-tetrazol-5-yl)[1,1'-bipheny l]-4-yl]methyl]-4(3H)-quinazolinone, sodium salt.
The compound 2-butyl-6-(1-methoxy-1-methylethyl)-3-[[2'-(1H-tetrazol-5-yl)[1,1'-bipheny l]-4-yl]methyl]-4(3H)-quinazolinone.
Dependencies are inferred from the claim text.