Photostabilizing method for ophthalmic solutions and the resulting ophthalmic solutions therefrom
AssigneesEisai Co., Ltd., Santen Pharmaceutical Co., Ltd.
InventorsTakakazu Morita, Shiro Mita, Yoichi Kawashima
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Abstract
This invention relates to a photostabilizing method for ophthalmic solutions and the resulting ophthalmic solutions therefrom. The stabilization is attained by adding polyhydric alcohol and boric acid, and/or sodium borate to ophthalmic solutions which contain a drug substance unstable against light.
Claims19
A photostabilizing method which comprises adding 0.1 to 2 g/100 ml of glycerol and 0.5 to 2.5 g/100 ml of boric acid, to an ophthalmic solution containing a drug substance which is unstable against light, the total amount of the glycerol and the boric acid compound being 1.5 to 3 g/100 ml.
An improved ophthalmic solution containing a drug substance which is unstable against light, the improvement comprising said ophthalmic solution further containing 0.1 to 2 g/100 ml of glycerol and 0.5 to 2.5 g/100 ml of boric acid, the total amount of the glycerol and the boric acid being 1.5 to 3 g/100 ml, to form a photostable ophthalmic solution.
A photostabilizing method which comprises adding a photostabilizing effective amount of 0.3 to 2 g/100 ml of glycerol and 0.5 to 2 g/100 ml of boric acid to an ophthalmic solution containing bunazosin hydrochloride, which is unstable against light, the total amount of the glycerol and the boric acid being 1.5 to 3 g/100 ml.
An improved ophthalmic solution comprising an ophthalmic solution containing bunazosin hydrochloride which is unstable against light, the improvement comprising said ophthalmic solution further containing a photostabilizing effective amount of 0.3 to 2 g/100 ml of glycerol and 0.5 to 2 g/100 ml of boric acid, wherein the total amount of the glycerol and the boric acid is 1.5 to 3 g/100 ml, to form a photostable ophthalmic solution.
Dependencies are inferred from the claim text.