US 5,290,772 AGranted

Immunosuppressant agent

AssigneeMerck & Co., Inc.

InventorsEdward S. Inamine, Shieh-Shung T. Chen, Byron H. Arison, Linda S. Wicker

Life of this patent

Estimating the term…

Abstract

Described is a process for producing an immunosuppressant, "demethimmunomycin" (L-683,7411) a C-31 demethylated analog of L-683,590 under fermentation conditions utilizing the microorganism, Actinoplanacete sp, (Merck Culture Collection MA 6559) ATCC No. 53771. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow and heart transplants.

Claims2

Dependent claims

An immunosuppressant, "demethimmunomycin", having the molecular structure:

##STR1##

Dependencies are inferred from the claim text.

Facts

Application: 07/899,235Filed 16 Jun 1992 · continuation
Priority: 29 Jun 1988
Granted: 1 Mar 1994
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

C12N 1/205
Bacteria; Culture media therefor: bacterial isolates
C07H 19/01
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives…
C12P 17/188
Containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin: heterocyclic…
C12R 2001/01
Microorganisms ; Processes using microorganisms: bacteria or Actinomycetales ; using bacteria or Actinomycetales

Family

Serial213,025Parent of this continuation · filed 29 Jun 1988
Serial423,481Parent of this continuation · filed 10 Oct 1989
US 5,290,772 AThis patent

From the US filing history. Foreign family members aren’t listed.

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