Cardioplegic compositions
AssigneeThe National Heart Foundation of New Zealand
InventorYee S. Choong
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Abstract
An aqueous cardioplegic solution providing significantly improved cardiac function after a period of exposure to cardioplegia, contains NaCl in the range of 70-110 mM; KCl in the range of 10-16 mM; CaCl.sub.2 in the range of 0.5-1.0 mM; MgCl.sub.2 in the range of 8-16 mM; NaHCO.sub.3 in the range of 10-20 mM; D-Glucose in the range of 5-15 mM; L-Aspartic acid in the range of 5-20 mM; and Lactobionic acid in the range of 0-15 mM.
Claims3
A sterile aqueous cardioplegic solution comprising NaCl in the range of 70-110 mM;
- KCl in the range of 10-16 mM;
- CaCl.sub.2 in the range of 0.5-1.0 mM;
- MgCl.sub.2 in the range of 8-16 mM;
- NaHCO.sub.3 in the range of 10-20 mM;
- D-Glucose in the range of 5-15 mM;
- L-Aspartic acid in the range of 5-20 mM;
- and Lactobionic acid in the range of 0-15 mM.
A method for creating a cardioplegic solution, in which the constituents are prepared and mixed as follows:
- (a) the required amounts of aspartic and lactobionic acids are each dissolved in a small amount of distilled water and neutralized to pH 7.5;
- (b) the cardioplegic solution is made by adding the various constituents in the sequence as listed here (1) NaCl, (2) KCl, (3) CaCl.sub.2, (4) MgCl.sub.2, (5) NaHCO.sub.3, (6) D-Glucose, (7) L-Aspartic acid, and (8) Lactobionic acid to a large volume (about 70% total) of distilled water, mixing the solution after each addition;
- (c) the balance of distilled water is added to the cardioplegic solution;
- (d) the cardioplegic solution is bubbled with a gaseous mixture of 95% oxygen:5% carbon dioxide for about 5 minutes;
- and
- (e) the cardioplegic solution is passed through a cardioplegic filter before use.
Dependencies are inferred from the claim text.