Stabilization of active plasminogen activator inhibitor-1
AssigneeThe DuPont Merck Pharmaceutical Company
InventorsJodie L. Duke, Jr., Harry L. Walton, Jr., Thomas M. Reilly
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Abstract
Processes for stabilizing active PAI-1 protein comprising combining active PAI-1 protein with an aqueous buffer having an ionic strength of at least about 5 millisiemens and a sugar selected from the group consisting of monosaccharides and disaccharides, and/or subjecting the active PAI-1 protein to lyophilization, are disclosed. Also described are compositions, including pharmaceutical compositions and kits, which include the stabilized active PAI-1 protein, and therapeutic processes employing the same in the treatment of fibrinolysis.
Claims12
A process for stabilizing active plasminogen activator inhibitor type-1 protein comprising combining said active plasminogen activator inhibitor type-1 protein with a buffer having an ionic strength of at least 5 millisiemens and a sugar selected form the group consisting of monosaccharides and disaccharides.
A composition comprising active plasminogen activator inhibitor type-1 protein in combination with a buffer having an ionic strength of at least 5 millisiemens and a sugar selected from the group consisting of monosaccharides and disaccharides.
Dependencies are inferred from the claim text.