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US 5,290,689 AGranted
New cyclic FR-900520 microbial biotransformation agent
AssigneeMerck & Co., Inc.
InventorsGeorge M. Garrity, Magda M. Gagliardi, Shieh-Shung T. Chen
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Abstract
Described is a process for producing a new immunosuppressant, a C-19/C-22 cyclic hemiketal (Compound I) biotransformation analog of FR-900520, under novel fermentation conditions utilizing the novel microorganism, Streptomyces sp. (Merck Culture Collection MA6969) ATCC No. 55280. The macrolide immunosuppressant is useful in preventing human host rejection of foreign organ transplants, e.g. bone marrow, liver, lung, kidney and heart transplants.
Claims4
A process for the production of an immunosuppressant compound having the structural formula I:
- ##STR3## the process comprising the steps of (a) culturing a microorganism Streptomyces sp. MA 6969 (ATCC No. 55280) in the presence of compound FR-900520 in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen under aerobic conditions until the compound is produced, and
- (b) recovering the compound.
Dependencies are inferred from the claim text.