Coated composition and its preparation process

Orally administrable coated granules of a pharmaceutically active substance stable to heat and sensitive to a solvent, which granules do not substantially release said pharmaceutically active substance during their stay in an oral cavity and, after passing through the oral cavity, dissolve or disintegrate quickly to release said pharmaceutically active substance and each granule being in a discrete form and comprising fine particles of said pharmaceutically active substance bound to each other by a first thermomelting polyethylene glycol material melting at a temperature of about 50.degree. to 150.degree. C. as a binder in an amount of from about 0.05 to 0.4 parts by weight to one part by weight of said pharmaceutically active substance and coated with a second thermomelting material which is a mixture of polyethylene glycol and a hydrophobic thermomelting material in a ratio of 1:2 by weight, said mixture having a melting point of about 50.degree. to 150.degree. C. but which is lower than the melting point of the first thermomelting polyethylene glycol material in an amount of from about 0.1 to 2 parts by weight to one part by weight of said granule, the coated granules being prepared from a mixture comprising fine particles of said pharmaceutically active substance and said first polyethylene glycol thermomelting material by a centrifuged force granulation procedure without using any solvent to form non-coated granules and subsequently coated the non-coated granules with said second thermomelting material by a centrifuged force coating procedure without using any solvent.