Loading patent…
AssigneeTakeda Chemical Industries, Ltd.
InventorsTatsuo Asogawa, Yoshitomi Kakiguchi, Seiji Izuhara
Estimating the term…
A method of producing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.-form thiamine hydrochloride crystals in the presence of .beta.-form thiamine hydrochloride crystals as seed crystals and stirring the mixture and a method of producing pharmaceutical preparations containing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.-form thiamine hydrochloride crystals, together with a binder, with water in the presence of .beta.-form thiamine hydrochloride crystals as seed crystals and stirring the mixture. .beta.-Form thiamine hydrochloride crystals which are stable and resistant to caking and pharmaceutical preparations containing the same can be produced in a simple and easy manner.
A method of producing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.-form thiamine hydrochloride crystals with water in the presence of about 1 to 30 weight percent, based on the weight of the .alpha.-form thiamine hydrochloride, .beta.-form thiamine hydrochloride crystals as seed crystals and agitating the resulting moistened mixture.
A method of producing a pharmaceutical preparation containing .beta.-form thiamine hydrochloride crystals which comprises moistening .alpha.-form thiamine hydrochloride crystals and a binder with water in the presence of about 1 to 30 hydrochloride, .beta.-form thiamine hydrochloride crystals as seed crystals and stirring the resulting moistened mixture.
Dependencies are inferred from the claim text.